Meyer-Lindenberg, Andreas Central Institute of Mental Health, Mannheim, Germany.
Weinberger, Daniel R. Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, National Institute of Mental Health, Bethesda, Maryland.
- Molecular action
- Brain systems involved in DARPP-32 effects
- DARPP-32 and human cognition
- DARPP-32 and drugs of abuse
- DARPP-32 and schizophrenia
- DARPP-32 and depression
- Additional Readings
Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (usually known by its acronym, DARPP-32) is a master molecular regulator in neurons that receive the neurotransmitter dopamine. For over two decades, an intense research effort has demonstrated that DARPP-32 occupies a unique position as a central molecular control point, integrating multiple information streams that converge through a variety of neurotransmitters, neuromodulators, neuropeptides, and steroid hormones onto dopaminoceptive neurons. Since dopaminergic neurotransmission is critical for motivated behavior, working memory, and reward-related learning and is implicated in, among other conditions, schizophrenia, alcoholism, Parkinson's disease, and pathological gambling, DARPP-32 has received considerable attention not only in basic neuroscience, but also in studies of the pathogenesis of these disorders and as a promising target for innovative drug treatment in psychiatry. In addition, DARPP-32 is found in nonneuronal tissues and may have relevance for certain types of cancer.
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