Wang, Chen Department of Pathology and Laboratory Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada.
Show previous versions
- Overview of stem cells
- Totipotent and embryonic stem cells
- Embryonic germ cells
- Growing mouse embryonic stem cells
- Growing human embryonic stem cells
- Adult stem cells
- Blood stem cells
- Isolating blood stem cells
- Umbilical cord blood and cord blood banks
- Mesenchymal stem cells
- Neural stem cells
- Potential clinical applications
- Somatic cell nuclear transfer stem cells
- Induced pluripotent stem cells
- Ethical and regulatory issues
- Links to Primary Literature
- Additional Readings
Cells that have the ability to self-replicate and to give rise to mature cells. The concept of stem cells (Fig. 1) was originally based on renewing tissues. Many adult tissues, including the skin, blood, and intestines, consist of mostly mature and short-lived cells that must be continuously replaced. Stem cells were postulated as the source of the self-renewal. In the early 1960s, Canadian scientists Ernest A. McCulloch and James E. Till provided the first experimental proof of the existence of stem cells in the blood system. They revealed that a type of cell in bone marrow possesses the capacity to replicate itself and to differentiate into various lineages of mature blood cells. Self-renewal, together with the capacity for differentiation, defined the properties of stem cells. This definition is generally used in stem cell biology today. See also: Cell (biology); Cell biology; Cell differentiation; Cell lineage
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Its dedicated editorial team is led by Sagan Award winner John Rennie. Contributors include more than 9000 highly qualified scientists and 42 Nobel Prize winners.
MORE THAN 8500 articles and Research Reviews covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 17,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information