Vaccines for schistosomiasis
McManus, Donald P. Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Queensland, Australia.
- Life-cycle features and transmission
- Immune response in schistosomiasis
- Strategies for vaccine development
- Status of vaccine development
- New antigen discovery
- Vaccine formulation
- Links to Primary Literature
- Additional Readings
Schistosomiasis, caused by trematode blood flukes of the genus Schistosoma, is the most important human helminth disease in terms of morbidity and mortality. The three major species infecting humans are Schistosoma mansoni (which occurs in much of sub-Saharan Africa, areas of South America, the Caribbean, Egypt, and the Arabian peninsula), S. haematobium [present in much of sub-Saharan Africa, Egypt, Sudan, the Maghreb (northwestern Africa), and the Arabian peninsula], and S. japonicum (endemic to southern China and the Philippines, with small foci in Indonesia). Schistosoma haematobium infections cause fibrosis, stricturing, and calcification of the urinary tract, whereas the other two species have well-described associations with chronic hepatic and intestinal fibrosis and their attendant consequences. Despite the existence of a highly effective antischistosome drug, praziquantel (PZQ), schistosomiasis is spreading into new areas, and, although it is the cornerstone of current control programs, PZQ chemotherapy does have limitations. Mass treatment does not prevent reinfection, and there is increasing concern about the development of parasite resistance to PZQ. Consequently, vaccine strategies represent an essential component for future control of schistosomiasis. An improved understanding of the immune response to schistosome infection, both in animal models and in humans, suggests that development of an effective vaccine is possible, although this goal has yet to be achieved.
The content above is only an excerpt.
for your institution. Subscribe
To learn more about subscribing to AccessScience, or to request a no-risk trial of this award-winning scientific reference for your institution, fill in your information and a member of our Sales Team will contact you as soon as possible.
to your librarian. Recommend
Let your librarian know about the award-winning gateway to the most trustworthy and accurate scientific information.
AccessScience provides the most accurate and trustworthy scientific information available.
Recognized as an award-winning gateway to scientific knowledge, AccessScience is an amazing online resource that contains high-quality reference material written specifically for students. Its dedicated editorial team is led by Sagan Award winner John Rennie. Contributors include more than 9000 highly qualified scientists and 42 Nobel Prize winners.
MORE THAN 8500 articles and Research Reviews covering all major scientific disciplines and encompassing the McGraw-Hill Encyclopedia of Science & Technology and McGraw-Hill Yearbook of Science & Technology
115,000-PLUS definitions from the McGraw-Hill Dictionary of Scientific and Technical Terms
3000 biographies of notable scientific figures
MORE THAN 17,000 downloadable images and animations illustrating key topics
ENGAGING VIDEOS highlighting the life and work of award-winning scientists
SUGGESTIONS FOR FURTHER STUDY and additional readings to guide students to deeper understanding and research
LINKS TO CITABLE LITERATURE help students expand their knowledge using primary sources of information